Gene
cyp3c3
- ID
- ZDB-GENE-041114-102
- Name
- cytochrome P450, family 3, subfamily c, polypeptide 3
- Symbol
- cyp3c3 Nomenclature History
- Previous Names
-
- cyp3c1l2 (1)
- zgc:101781
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable steroid hydroxylase activity. Predicted to be located in membrane. Is expressed in several structures, including adaxial cell; heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A43 (cytochrome P450 family 3 subfamily A member 43); and CYP3A5 (cytochrome P450 family 3 subfamily A member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101781 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450 3A | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:E9QEE5 | InterPro | 503 | |||||
| UniProtKB:A0A8M6Z4Z2 | InterPro | 503 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp3c3-201
(1)
|
Ensembl | 2,225 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-21N8 | Corley-Smith et al., 2006 | |
| Encodes | cDNA | MGC:101781 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193072 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007400 (1) | 2227 nt | ||
| Genomic | GenBank:BX649536 (1) | 203180 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z4Z2 (1) | 503 aa |
No data available
- Nawaji, T., Yamashita, N., Umeda, H., Zhang, S., Mizoguchi, N., Seki, M., Kitazawa, T., Teraoka, H. (2020) Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish. Pharmaceuticals (Basel, Switzerland). 13(12):
- Kubota, A., Kawai, Y.K., Yamashita, N., Lee, J.S., Kondoh, D., Zhang, S., Nishi, Y., Suzuki, K., Kitazawa, T., Teraoka, H. (2019) Transcriptional profiling of cytochrome P450 genes in the liver of adult zebrafish, Danio rerio. The Journal of Toxicological Sciences. 44:347-356
- Shaya, L., Jones, D.E., Wilson, J.Y. (2018) CYP3C gene regulation by the aryl hydrocarbon and estrogen receptors in zebrafish. Toxicology and applied pharmacology. 362:77-85
- Yang, Y., Ji, D., Huang, X., Zhang, J., Liu, J. (2017) Effects of metals on enantioselective toxicity and biotransformation of cis-bifenthrin in zebrafish. Environmental toxicology and chemistry. 36(8):2139-2146
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Shaya, L., Dejong, C., Wilson, J.Y. (2014) Expression Patterns of Cytochrome P450 3B and 3C Genes in Model Fish Species. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 166:115-25
- Li, Z.H., Alex, D., Siu, S.O., Chu, I.K., Renn, J., Winkler, C., Lou, S., Tsui, S.K., Zhao, H.Y., Yan, W.R., Mahady, G.B., Li, G.H., Kwan, Y.W., Wang, Y.T., and Lee, S.M. (2011) Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae. Molecular Biosystems. 7(7):2128-38
- Lerebours, A., Gonzalez, P., Adam, C., Camilleri, V., Bourdineaud, J.P., and Garnier-Laplace, J. (2009) Comparative Analysis Of Gene Expression In Brain, Liver, Skeletal Muscles And Gills Of The Zebrafish (Danio rerio) Exposed To Environmentally Relevant Waterborne Uranium Concentrations. Environmental toxicology and chemistry. 28(6):1271-1278
- Thomas, J.H. (2007) Rapid birth-death evolution specific to xenobiotic cytochrome P450 genes in vertebrates. PLoS Genetics. 3(5):e67
- Corley-Smith, G.E., Su, H.T., Wang-Buhler, J.L., Tseng, H.P., Hu, C.H., Hoang, T., Chung, W.G., and Buhler, D.R. (2006) CYP3C1, the first member of a new cytochrome P450 subfamily found in zebrafish (Danio rerio). Biochemical and Biophysical Research Communications. 340(4):1039-46
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