Gene
ezh2
- ID
- ZDB-GENE-041111-259
- Name
- enhancer of zeste 2 polycomb repressive complex 2 subunit
- Symbol
- ezh2 Nomenclature History
- Previous Names
-
- eya2
- im:7149338
- zgc:136376
- zgc:152758
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables histone H3K27 methyltransferase activity; transcription coactivator activity; and transcription regulator activator activity. Involved in positive regulation of circadian rhythm and positive regulation of hemopoiesis. Acts upstream of or within several processes, including digestive tract development; fin regeneration; and tissue homeostasis. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; digestive system; eye; gonad; and intermediate cell mass of mesoderm. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7149338 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Weaver syndrome | Alliance | Weaver syndrome | 277590 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001005 | SANT/Myb domain |
| Domain | IPR001214 | SET domain |
| Domain | IPR026489 | CXC domain |
| Domain | IPR033467 | Tesmin/TSO1-like CXC domain |
| Domain | IPR041343 | Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain |
| Domain | IPR041355 | Pre-SET CXC domain |
| Domain | IPR044439 | EZH2, SET domain |
| Domain | IPR048358 | EZH1/2, MCSS domain |
| Family | IPR021654 | Histone-lysine N-methyltransferase EZH1/EZH2 |
| Family | IPR045318 | Histone-lysine N-methyltransferase EZH1/2-like |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | CXC domain | EZH1/2, MCSS domain | EZH2, SET domain | Histone-lysine N-methyltransferase EZH1/2-like | Histone-lysine N-methyltransferase EZH1/EZH2 | Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain | Pre-SET CXC domain | SANT/Myb domain | SET domain | SET domain superfamily | Tesmin/TSO1-like CXC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q08BS4
|
760 |
Interactions and Pathways
No data available
Plasmids
No data available