Gene

hadhab

ID

ZDB-GENE-041111-204

Name

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b

Symbol

hadhab Nomenclature History

Previous Names

im:7144234
zgc:158138 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to localize to mitochondrial fatty acid beta-oxidation multienzyme complex. Human ortholog(s) of this gene implicated in fatty liver disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7144234 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hadhab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mitochondrial trifunctional protein deficiency 1	Alliance	Mitochondrial trifunctional protein deficiency 1	609015
		Fatty liver, acute, of pregnancy	609016
		HELLP syndrome, maternal, of pregnancy	609016
		LCHAD deficiency	609016

Associated With hadhab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR006180	3-hydroxyacyl-CoA dehydrogenase, conserved site
Conserved_site	IPR018376	Enoyl-CoA hydratase/isomerase, conserved site
Domain	IPR006108	3-hydroxyacyl-CoA dehydrogenase, C-terminal
Domain	IPR006176	3-hydroxyacyl-CoA dehydrogenase, NAD binding
Family	IPR001753	Enoyl-CoA hydratase/isomerase
Family	IPR012803	Fatty acid oxidation complex, alpha subunit, mitochondrial
Family	IPR050136	Fatty acid oxidation complex subunit alpha
Homologous_superfamily	IPR008927	6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
Homologous_superfamily	IPR029045	ClpP/crotonase-like domain superfamily
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily