Gene
atg4da
- ID
- ZDB-GENE-041111-102
- Name
- autophagy related 4D, cysteine peptidase a
- Symbol
- atg4da Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase activity and protein-phosphatidylethanolamide deconjugating activity. Acts upstream of or within cerebellar Purkinje cell differentiation and cerebellar neuron development. Predicted to be active in cytoplasm. Orthologous to human ATG4D (autophagy related 4D cysteine peptidase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7140072 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Kyöstilä et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Papain-like cysteine peptidase superfamily | Peptidase C54 | Peptidase C54, catalytic domain |
|---|---|---|---|---|
|
UniProtKB:R4GER2
|
485 | |||
|
UniProtKB:A0A8M9Q0Z1
|
485 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atg4da-201
(1)
|
Ensembl | 1,392 nt | ||
| mRNA |
atg4da-202
(1)
|
Ensembl | 4,671 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-212H16 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7140072 | Thisse et al., 2004 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423806 (1) | 4774 nt | ||
| Genomic | GenBank:BX547996 (1) | 213398 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q0Z1 (1) | 485 aa |
- Huang, G., Zhang, F., Ye, Q., Wang, H. (2016) The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish. Autophagy. 12(8):1292-309
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kyöstilä, K., Syrjä, P., Jagannathan, V., Chandrasekar, G., Jokinen, T.S., Seppälä, E.H., Becker, D., Drögemüller, M., Dietschi, E., Drögemüller, C., Lang, J., Steffen, F., Rohdin, C., Jäderlund, K.H., Lappalainen, A.K., Hahn, K., Wohlsein, P., Baumgärtner, W., Henke, D., Oevermann, A., Kere, J., Lohi, H., Leeb, T. (2015) A Missense Change in the ATG4D Gene Links Aberrant Autophagy to a Neurodegenerative Vacuolar Storage Disease. PLoS Genetics. 11:e1005169
1 - 3 of 3
Show