Gene

dll4

ID

ZDB-GENE-041014-73

Name

delta-like 4 (Drosophila)

Symbol

dll4 Nomenclature History

Previous Names

si:ch211-244p18.5
zgc:136596

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have Notch binding activity. Involved in several processes, including negative regulation of blood vessel endothelial cell migration; regulation of vascular endothelial growth factor receptor signaling pathway; and vasculature development. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Is expressed in several structures, including atrioventricular canal endocardium; brain; pronephric duct; vasculature; and xanthophore. Orthologous to human DLL4 (delta like canonical Notch ligand 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

67 figures from 54 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 35 figures from 26 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dll4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Adams-Oliver syndrome 6	616589

Associated With dll4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001774	Delta/Serrate/lag-2 (DSL) protein
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR011651	Notch ligand, N-terminal domain
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site