Gene
pla2g4ab
- ID
- ZDB-GENE-041014-325
- Name
- phospholipase A2, group IVAb (cytosolic, calcium-dependent)
- Symbol
- pla2g4ab Nomenclature History
- Previous Names
-
- pla2g4a
- si:dkey-97o5.1
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables phospholipase activity. Acts upstream of or within regulation of G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including Golgi apparatus; cytosol; and endoplasmic reticulum. Is expressed in midbrain; ovarian follicle stage I; ovarian follicle stage II; ovarian follicle stage III; and ovarian follicle stage IV. Orthologous to human PLA2G4A (phospholipase A2 group IVA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Naini et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Gastrointestinal ulceration, recurrent, with dysfunctional platelets | 618372 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR002642 | Lysophospholipase, catalytic domain |
| Domain | IPR041847 | Cytosolic phospholipase A2, C2 domain |
| Homologous_superfamily | IPR016035 | Acyl transferase/acyl hydrolase/lysophospholipase |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Acyl transferase/acyl hydrolase/lysophospholipase | C2 domain | C2 domain superfamily | Cytosolic phospholipase A2, C2 domain | Lysophospholipase, catalytic domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YV03 | InterPro | 722 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pla2g4ab-201
(1)
|
Ensembl | 2,154 nt | ||
| mRNA |
pla2g4ab-202
(1)
|
Ensembl | 2,684 nt | ||
| mRNA |
pla2g4ab-203
(1)
|
Ensembl | 2,163 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-169J21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-97O5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017352702 (1) | |||
| Genomic | GenBank:BX248238 (1) | 158302 nt | ||
| Polypeptide | UniProtKB:A0A8M6YV03 (1) | 722 aa |
- Ramachandran, D., Sharma, K., Saxena, V., Nipu, N., Rajapaksha, D.C., Mennigen, J.A. (2023) Knock-out of vasotocin reduces reproductive success in female zebrafish, Danio rerio. Frontiers in endocrinology. 14:11512991151299
- Cacialli, P., Mailhe, M.P., Wagner, I., Merkler, D., Golub, R., Bertrand, J.Y. (2022) Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates. The EMBO journal. 41(19):e108536
- Wu, S., Chen, K., Xu, T., Ma, K., Gao, L., Fu, C., Zhang, W., Jing, C., Ren, C., Deng, M., Chen, Y., Zhou, Y., Pan, W., Jia, X. (2021) Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis. Frontiers in cell and developmental biology. 9:709923
- Ma, Y., Wu, Y., Xia, Z., Li, J., Li, X., Xu, P., Zhou, X., Xue, M. (2019) Anti-Hypoxic Molecular Mechanisms of Rhodiola crenulata Extract in Zebrafish as Revealed by Metabonomics. Frontiers in pharmacology. 10:1356
- Tang, H., Wang, L., Chen, Y., He, J., Qu, L., Guo, Y., Liu, Y., Liu, X., Lin, H. (2018) Ovulation is associated with the LH-dependent induction of pla2g4aa in zebrafish. Molecular and Cellular Endocrinology. 473:53-60
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Naini, S.M., Choukroun, G.J., Ryan, J.R., Hentschel, D.M., Shah, J.V., Bonventre, J.V. (2016) Cytosolic phospholipase A2α regulates G1 progression through modulating FOXO1 activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(3):1155-70
- Miller, G.W., Labut, E.M., Lebold, K.M., Floeter, A., Tanguay, R.L., and Traber, M.G. (2012) Zebrafish (Danio rerio) fed vitamin E-deficient diets produce embryos with increased morphologic abnormalities and mortality. The Journal of Nutritional Biochemistry. 23(5):478-486
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
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