Gene

ercc8

ID
ZDB-GENE-041010-60
Name
excision repair cross-complementation group 8
Symbol
ercc8 Nomenclature History
Previous Names
  • CSA (1)
  • zgc:103550
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Acts upstream of or within response to UV. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and nucleotide-excision repair complex. Human ortholog(s) of this gene implicated in Cockayne syndrome; Cockayne syndrome A; and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa10326Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-ercc8N/AWu et al., 2019
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Human Disease
Associated With ercc8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cockayne syndrome A Alliance Cockayne syndrome, type A 216400
UV-sensitive syndrome Alliance UV-sensitive syndrome 2 614621
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Associated With ercc8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019775 WD40 repeat, conserved site
Family IPR042238 DNA excision repair protein Rad28/ERCC8/Ckn1/ATCSA-1
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR001680 WD40 repeat
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Domain Details Per Protein
Protein Length DNA excision repair protein Rad28/ERCC8/Ckn1/ATCSA-1 G-protein beta WD-40 repeat WD40 repeat WD40 repeat, conserved site WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q5XJ81 400
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 8
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ercc8-201 (1) Ensembl 1,863 nt
mRNA ercc8-203 (1) Ensembl 783 nt
ncRNA ercc8-003 (1) Ensembl 990 nt
ncRNA ercc8-004 (1) Ensembl 437 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-198N5ZFIN Curated Data
EncodescDNAMGC:103550ZFIN Curated Data
EncodescDNAMGC:173776ZFIN Curated Data
EncodescDNAMGC:174726ZFIN Curated Data
EncodescDNAMGC:192920ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanERCC85
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseErcc813
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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