Gene

serpina7

ID

ZDB-GENE-041010-47

Name

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

Symbol

serpina7 Nomenclature History

Previous Names

wu:fb66f08
wu:fb68e04
zgc:103617

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be active in extracellular space. Is expressed in blood and liver. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; chronic obstructive pulmonary disease; corticosteroid-binding globulin deficiency; cystic fibrosis; and vasculitis. Orthologous to several human genes including SERPINA7 (serpin family A member 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103617 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With serpina7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		[Thyroxine-binding globulin QTL]	300932

Associated With serpina7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023795	Serpin, conserved site
Domain	IPR023796	Serpin domain
Family	IPR000215	Serpin family
Homologous_superfamily	IPR036186	Serpin superfamily
Homologous_superfamily	IPR042178	Serpin superfamily, domain 1
Homologous_superfamily	IPR042185	Serpin superfamily, domain 2