Gene

ppp2r2bb

ID

ZDB-GENE-041010-39

Name

protein phosphatase 2, regulatory subunit B, beta b

Symbol

ppp2r2bb Nomenclature History

Previous Names

ppp2r2b
zgc:101861

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have protein phosphatase regulator activity. Predicted to be involved in peptidyl-serine dephosphorylation. Predicted to localize to cytosol and protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:101861 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppp2r2bb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spinocerebellar ataxia type 12	Alliance	Spinocerebellar ataxia 12	604326

Associated With ppp2r2bb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018067	Protein phosphatase 2A regulatory subunit PR55, conserved site
Family	IPR000009	Protein phosphatase 2A regulatory subunit PR55
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Protein phosphatase 2A regulatory subunit PR55	Protein phosphatase 2A regulatory subunit PR55, conserved site	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A2R8Q610 InterPro	446
UniProtKB:A0A8M9PCQ6 InterPro	433
UniProtKB:A0A0R4IEA6 InterPro	443

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ppp2r2bb-201 (1) Ensembl	Havana	491 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ppp2r2bb-202 (1) Ensembl	Havana	1920 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations