Gene
rad51c
- ID
- ZDB-GENE-041010-204
- Name
- RAD51 paralog C
- Symbol
- rad51c Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to contribute to crossover junction endodeoxyribonuclease activity and four-way junction DNA binding activity. Predicted to be involved in DNA repair and reciprocal meiotic recombination. Predicted to colocalize with Holliday junction resolvase complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101596 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fanconi anemia complementation group O | Alliance | Fanconi anemia, complementation group O | 613390 |
| {Breast-ovarian cancer, familial, susceptibility to, 3} | 613399 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Fanconi anemia | rad51chg65/hg65 (NHGRI-1) | standard conditions | Raman et al., 2021 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR013632 | DNA recombination and repair protein Rad51-like, C-terminal |
| Domain | IPR020588 | DNA recombination and repair protein RecA-like, ATP-binding domain |
| Family | IPR016467 | DNA recombination and repair protein, RecA-like |
| Family | IPR052093 | Homologous Recombination Repair Mediator |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | DNA recombination and repair protein Rad51-like, C-terminal | DNA recombination and repair protein, RecA-like | DNA recombination and repair protein RecA-like, ATP-binding domain | Homologous Recombination Repair Mediator | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QC24
|
362 | ||||||
|
UniProtKB:A0A8M9QKP1
|
337 | ||||||
|
UniProtKB:Q5XJT2
|
362 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rad51c-201
(1)
|
Ensembl | 1,743 nt | ||
| mRNA |
rad51c-202
(1)
|
Ensembl | 1,638 nt |
Interactions and Pathways
No data available
Plasmids
No data available