Gene
tpmt.2
- ID
- ZDB-GENE-041010-177
- Name
- thiopurine S-methyltransferase, tandem duplicate 2
- Symbol
- tpmt.2 Nomenclature History
- Previous Names
-
- si:ch73-345a19.3
- zgc:101684
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have thiopurine S-methyltransferase activity. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alopecia; leukopenia; and thiopurine S-methyltransferase deficiency. Orthologous to human TPMT (thiopurine S-methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| poor metabolism of thiopurines 1 | Alliance | {Thiopurines, poor metabolism of, 1} | 610460 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Thiopurine S-methyltransferase | TPMT family |
|---|---|---|---|---|
|
UniProtKB:Q5XJQ2
|
246 | |||
|
UniProtKB:F8W621
|
232 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
tpmt.2-202
(1)
|
Ensembl | 993 nt | ||
| mRNA |
tpmt.2-201
(1)
|
Ensembl | 748 nt | ||
| mRNA |
tpmt.2-203
(1)
|
Ensembl | 748 nt |
Interactions and Pathways
No data available
Plasmids
No data available