Gene

ank2b

ID

ZDB-GENE-041010-165

Name

ankyrin 2b, neuronal

Symbol

ank2b Nomenclature History

Previous Names

ank2
zgc:101738 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in protein localization to T-tubule and regulation of cardiac muscle contraction. Predicted to act upstream of or within proteolysis and signal transduction. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in T-tubule. Is expressed in central nervous system; cranial ganglion; optic vesicle; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:101738 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ank2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
ankyrin-B-related cardiac arrhythmia	Alliance	Cardiac arrhythmia, ankyrin-B-related	600919
ankyrin-B-related cardiac arrhythmia	Alliance	Long QT syndrome 4	600919

Associated With ank2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR001969	Aspartic peptidase, active site
Domain	IPR000488	Death domain
Domain	IPR000906	ZU5 domain
Domain	IPR040745	Ankyrin, UPA domain
Family	IPR051165	Multifunctional Ankyrin Repeat Domain-Containing Protein
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	Ankyrin, UPA domain	Aspartic peptidase, active site	Death domain	Death-like domain superfamily	Multifunctional Ankyrin Repeat Domain-Containing Protein	ZU5 domain
UniProtKB:A0A8M9Q7R7 InterPro	3532
UniProtKB:A0A8M9Q1F0 InterPro	3626
UniProtKB:A0A8M9QBV6 InterPro	3608
UniProtKB:A0A8M9PNT0 InterPro	3622
UniProtKB:A0A8M9Q7R2 InterPro	3603
UniProtKB:A0A8M9PNV7 InterPro	1513
UniProtKB:A0A8M9QBY0 InterPro	2668
UniProtKB:A0A8M9Q7T1 InterPro	1991
UniProtKB:A0A8M9QGV2 InterPro	3608
UniProtKB:A0A8M9Q1I9 InterPro	2002
UniProtKB:A0A8M9PNS3 InterPro	3630
UniProtKB:A0A8M9QGU1 InterPro	3631
UniProtKB:A0A8M1PAL4 InterPro	1754
UniProtKB:A0A8M9QGV9 InterPro	3601
UniProtKB:A0A8M9QGW4 InterPro	3508
UniProtKB:A0A8M9Q7S2 InterPro	3308
UniProtKB:A0A8M9Q1H0 InterPro	3563
UniProtKB:A0A8M9PNT8 InterPro	3589
UniProtKB:A0A8M9QBW8 InterPro	3502
UniProtKB:A0A8M9PNT4 InterPro	3604
UniProtKB:A0A8M9Q1F7 InterPro	3620
UniProtKB:A0A8M9QBW2 InterPro	3596
UniProtKB:A0A8M9Q7S6 InterPro	2679
UniProtKB:A0A8M9PNU3 InterPro	3483
UniProtKB:A0A8M9QBY5 InterPro	1524
UniProtKB:A0A8M9QGX0 InterPro	3276
UniProtKB:A0A8M9Q1G4 InterPro	3604
UniProtKB:A0A8M9QGX6 InterPro	2669
UniProtKB:A0A8M9Q1H7 InterPro	3482
UniProtKB:A0A8M9PNV1 InterPro	2598
UniProtKB:A0A8M9QBV0 InterPro	3622
UniProtKB:A0A8M9QBX3 InterPro	3275
UniProtKB:A0A8M9Q7Q0 InterPro	3633
UniProtKB:A0A8M9Q1I2 InterPro	2680
UniProtKB:A0A8M9Q1E3 InterPro	3634
UniProtKB:A0A8M9QGU6 InterPro	3623
UniProtKB:A0A8M9Q7Q4 InterPro	3623
UniProtKB:A0A8M9Q7Q9 InterPro	3616
UniProtKB:A0A8M9PNU7 InterPro	2805
UniProtKB:A0A8M9QGY1 InterPro	1882

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ank2b-201 (1) Ensembl	Ensembl	1,495 nt	Select Tool ZFIN BLAST
mRNA	ank2b-202 (1) Ensembl	Ensembl	294 nt	Select Tool ZFIN BLAST
mRNA	ank2b-203 (1) Ensembl	Ensembl	713 nt	Select Tool ZFIN BLAST
mRNA	ank2b-204 (1) Ensembl	Ensembl	1,401 nt	Select Tool ZFIN BLAST
mRNA	ank2b-205 (1) Ensembl	Ensembl	11,061 nt	Select Tool ZFIN BLAST
mRNA	ank2b-206 (1) Ensembl	Ensembl	6,814 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations