Gene

atl3

ID

ZDB-GENE-041010-109

Name

atlastin 3

Symbol

atl3 Nomenclature History

Previous Names

im:6911985
zgc:103512

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have GTP binding activity and GTPase activity. Predicted to be involved in endoplasmic reticulum organization and protein homooligomerization. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1F. Orthologous to human ATL3 (atlastin GTPase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6911985 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atl3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary sensory neuropathy type 1F	Alliance	Neuropathy, hereditary sensory, type IF	615632

Associated With atl3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003191	Guanylate-binding protein/Atlastin, C-terminal
Domain	IPR015894	Guanylate-binding protein, N-terminal
Domain	IPR030386	GB1/RHD3-type guanine nucleotide-binding (G) domain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036543	Guanylate-binding protein, C-terminal domain superfamily

Domain Details Per Protein

Protein	Length	GB1/RHD3-type guanine nucleotide-binding (G) domain	Guanylate-binding protein/Atlastin, C-terminal	Guanylate-binding protein, C-terminal domain superfamily	Guanylate-binding protein, N-terminal	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A2CEM4 InterPro	513
UniProtKB:Q5XJ96 InterPro	513

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	atl3-201 (1) Ensembl	Ensembl	3,594 nt	Select Tool
mRNA	atl3-202 (1) Ensembl	Ensembl	951 nt	Select Tool
mRNA	atl3-203 (1) Ensembl	Ensembl	739 nt	Select Tool
mRNA	atl3-204 (1) Ensembl	Ensembl	749 nt	Select Tool
mRNA	atl3-205 (1) Ensembl	Ensembl	1,938 nt	Select Tool ZFIN BLAST
mRNA	atl3-206 (1) Ensembl	Ensembl	2,066 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations