Gene

usp4

ID

ZDB-GENE-041008-187

Name

ubiquitin specific peptidase 4 (proto-oncogene)

Symbol

usp4 Nomenclature History

Previous Names

im:7139722
unpEL (1)
wu:fa11d11

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have thiol-dependent ubiquitin-specific protease activity. Involved in convergent extension; negative regulation of toll-like receptor signaling pathway; and protein deubiquitination. Predicted to localize to nucleus. Orthologous to human USP4 (ubiquitin specific peptidase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7139722 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With usp4 Human Ortholog

No data available

Associated With usp4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018200	Ubiquitin specific protease, conserved site
Domain	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain	IPR006615	Peptidase C19, ubiquitin-specific peptidase, DUSP domain
Domain	IPR028135	Ubiquitin-like domain, USP-type
Domain	IPR028889	Ubiquitin specific protease domain
Domain	IPR029346	Ubiquitin carboxyl-terminal hydrolase, C-terminal
Homologous_superfamily	IPR035927	DUSP-like superfamily
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily

Domain Details Per Protein

Protein	Length	DUSP-like superfamily	Papain-like cysteine peptidase superfamily	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	Peptidase C19, ubiquitin-specific peptidase, DUSP domain	Ubiquitin carboxyl-terminal hydrolase, C-terminal	Ubiquitin-like domain, USP-type	Ubiquitin specific protease, conserved site	Ubiquitin specific protease domain
UniProtKB:E7EZD6 InterPro	1009

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	usp4-201 (1) Ensembl	Havana	4871 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations