ZFIN is now using GRCz12tu for Genomic Data
Gene
flncb
- ID
- ZDB-GENE-041008-175
- Name
- filamin C, gamma b (actin binding protein 280)
- Symbol
- flncb Nomenclature History
- Previous Names
-
- im:7139256
- sot
- wu:fc02d03
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and nervous system development. Predicted to be located in cytoskeleton. Is expressed in several structures, including adaxial cell; optic vesicle; primitive heart tube; retina; and skeletal muscle cell. Used to study autosomal dominant polycystic kidney disease and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in distal myopathy 4; hypertrophic cardiomyopathy 26; and myofibrillar myopathy 5. Orthologous to human FLNC (filamin C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139256 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| distal myopathy 4 | Alliance | Myopathy, distal, 4 | 614065 |
| hypertrophic cardiomyopathy 26 | Alliance | Arrhythmogenic right ventricular dysplasia, familial | 617047 |
| hypertrophic cardiomyopathy 26 | Alliance | Cardiomyopathy, familial hypertrophic, 26 | 617047 |
| hypertrophic cardiomyopathy 26 | Alliance | Cardiomyopathy, familial restrictive 5 | 617047 |
| myofibrillar myopathy 5 | Alliance | Myopathy, myofibrillar, 5 | 609524 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autosomal dominant polycystic kidney disease | WT + MO1-flncb | standard conditions | Adams et al., 2012 |
| dilated cardiomyopathy | WT + MO2-flncb + MO4-tp53 | standard conditions | Begay et al., 2016 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001589 | Actinin-type actin-binding domain, conserved site |
| Domain | IPR001715 | Calponin homology domain |
| Family | IPR044801 | Filamin family |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR036872 | CH domain superfamily |
| Repeat | IPR001298 | Filamin/ABP280 repeat |
| Repeat | IPR017868 | Filamin/ABP280 repeat-like |
Domain Details Per Protein
| Protein | Additional Resources | Length | Actinin-type actin-binding domain, conserved site | Calponin homology domain | CH domain superfamily | Filamin/ABP280 repeat | Filamin/ABP280 repeat-like | Filamin family | Immunoglobulin E-set | Immunoglobulin-like fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PV14 | InterPro | 2691 | ||||||||
| UniProtKB:A0A8M9PHR9 | InterPro | 2773 | ||||||||
| UniProtKB:A0A8M9Q104 | InterPro | 2742 | ||||||||
| UniProtKB:A0A8M9PHS4 | InterPro | 2701 | ||||||||
| UniProtKB:A0A8M9Q107 | InterPro | 2660 | ||||||||
| UniProtKB:A0A8M9PV09 | InterPro | 2772 | ||||||||
| UniProtKB:A0A8M9Q696 | InterPro | 2731 | ||||||||
| UniProtKB:A0A8M9QBS4 | InterPro | 2732 | ||||||||
| UniProtKB:A0A8M9Q6A0 | InterPro | 2649 | ||||||||
| UniProtKB:A0A8M9QBT0 | InterPro | 2619 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers