Gene
kri1
- ID
- ZDB-GENE-040915-3
- Name
- KRI1 homolog
- Symbol
- kri1 Nomenclature History
- Previous Names
-
- kri1l (1)
- flj12949l
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Acts upstream of or within definitive hemopoiesis and ribosome biogenesis. Predicted to be part of 90S preribosome. Predicted to be active in nucleolus. Is expressed in eye; immature eye; and somite. Orthologous to human KRI1 (KRI1 homolog).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Jia et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cas002 | Allele with one point mutation | Donor Splice Site of Intron 1 | Splice Site, Frameshift, Premature Stop | ENU | |
| hi2155Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| sa6032 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa10565 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30604 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33139 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40037 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-kri1 | N/A | Jia et al., 2015 |
| MO2-kri1 | N/A | Jia et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Kri1-like, C-terminal | KRR1 interacting protein 1 |
|---|---|---|---|---|
| UniProtKB:Q6DRJ4 | InterPro | 765 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-224D23 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195335 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002041 (1) | 2572 nt | ||
| Genomic | GenBank:BX322663 (2) | 145520 nt | ||
| Polypeptide | UniProtKB:Q6DRJ4 (1) | 765 aa |
- Choi, M.K., Cook, A., Mungikar, K., Eachus, H., Tochwin, A., Linke, M., Gerber, S., Ryu, S. (2024) Exposure to elevated glucocorticoid during development primes altered transcriptional responses to acute stress in adulthood. iScience. 27:110160110160
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Jia, X.E., Ma, K., Xu, T., Gao, L., Wu, S., Fu, C., Zhang, W., Wang, Z., Liu, K., Dong, M., Jing, C., Ren, C., Dong, Z., Chen, Y., Jin, Y., Huang, Q., Chang, X., Deng, M., Li, L., Luo, L., Zhu, J., Dang, Y., Chang, H.C., Zon, L.I., Zhou, Y., Chen, S., Pan, W. (2015) Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Research. 25(8):946-62
- Ju, Z., Wells, M.C., Martinez, A., Hazlewood, L., and Walter, R.B. (2005) An in silico mining for simple sequence repeats from expressed sequence tags of zebrafish, medaka, Fundulus, and Xiphophorus. In Silico Biology. 5(5-6):439-463
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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