Gene
adprs
- ID
- ZDB-GENE-040912-85
- Name
- ADP-ribosylserine hydrolase
- Symbol
- adprs Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have O-acetyl-ADP-ribose deacetylase activity; hydrolase activity, acting on glycosyl bonds; and magnesium ion binding activity. Predicted to be involved in DNA repair and peptidyl-serine ADP-deribosylation. Predicted to localize to mitochondrion; nucleus; and site of DNA damage. Human ortholog(s) of this gene implicated in stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human ADPRS (ADP-ribosylserine hydrolase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7143915 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| stress-induced childhood-onset neurodegeneration with variable ataxia and seizures | Alliance | Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures | 618170 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ADP-ribosylation/Crystallin J1 | ADP-ribosylation/Crystallin J1 superfamily | ADP-ribosylglycohydrolase |
|---|---|---|---|---|
|
UniProtKB:Q66HT8
|
370 | |||
|
UniProtKB:A0A8M3ARH3
|
203 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adprhl2-201
(1)
|
Ensembl | 1,615 nt |
Interactions and Pathways
No data available
Plasmids
No data available