Gene
rassf1
- ID
- ZDB-GENE-040912-14
- Name
- Ras association domain family member 1
- Symbol
- rassf1 Nomenclature History
- Previous Names
-
- wu:fc17f02
- zgc:112224
- zgc:92505
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within intracellular signal transduction and regulation of microtubule cytoskeleton organization. Predicted to be located in cytoplasm and microtubule. Predicted to be active in microtubule cytoskeleton and nucleus. Is expressed in several structures, including immature eye; intermediate cell mass of mesoderm; nervous system; pharyngeal arch; and ventral mesoderm. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human RASSF1 (Ras association domain family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92505 (16 images)
- IMAGE:6912198 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000159 | Ras-associating domain |
| Domain | IPR001368 | TNFR/NGFR cysteine-rich region |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR011524 | SARAH domain |
| Domain | IPR033600 | Ras association domain-containing protein 1, RA domain |
| Family | IPR033614 | Ras association domain-containing protein 1-6 |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | C1-like domain superfamily | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Ras-associating domain | Ras association domain-containing protein 1-6 | Ras association domain-containing protein 1, RA domain | SARAH domain | TNFR/NGFR cysteine-rich region | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66HV2
|
363 | ||||||||
|
UniProtKB:A0A8M2BL97
|
340 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rassf1-201
(1)
|
Ensembl | 1,597 nt | ||
| mRNA |
rassf1-202
(1)
|
Ensembl | 2,159 nt | ||
| mRNA |
rassf1-203
(1)
|
Ensembl | 1,432 nt |
Interactions and Pathways
No data available
Plasmids
No data available