Gene
aqp8a.1
- ID
- ZDB-GENE-040912-106
- Name
- aquaporin 8a, tandem duplicate 1
- Symbol
- aqp8a.1 Nomenclature History
- Previous Names
-
- aqp8
- aqp8a
- aqp8aa (1)
- db04c12
- mg:db04c12
- zgc:103682
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables urea transmembrane transporter activity and water transmembrane transporter activity. Predicted to be involved in water transport. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; eye; liver; mesoderm; and pleuroperitoneal region. Orthologous to human AQP8 (aquaporin 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103682 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| is13Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR2-aqp8a.1 | Wierson et al., 2020 | |
| CRISPR3-aqp8a.1 | Chen et al., 2024 | |
| MO1-aqp8a.1 | N/A | Chen et al., 2024 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aquaporin 8 | Aquaporin-like | Aquaporin transporter | Major intrinsic protein |
|---|---|---|---|---|---|---|
| UniProtKB:Q66I64 | InterPro | 260 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aqp8a.1-201
(1)
|
Ensembl | 1,029 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fli1:aqp8a.1-EGFP) |
|
| 1 | Chen et al., 2024 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218L14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-69N5 | ||
| Contains | SNP | rs3728482 | ZFIN Curated Data | |
| Contains | SNP | rs3728483 | ZFIN Curated Data | |
| Contains | SNP | rs3728484 | ZFIN Curated Data | |
| Contains | SNP | rs3728485 | ZFIN Curated Data | |
| Contains | SNP | rs3728486 | ZFIN Curated Data | |
| Contains | SNP | rs3728487 | ZFIN Curated Data | |
| Contains | SNP | rs3728488 | ZFIN Curated Data | |
| Contains | SNP | rs3728489 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004661 (1) | 1045 nt | ||
| Genomic | GenBank:CR352324 (1) | 206894 nt | ||
| Polypeptide | UniProtKB:Q66I64 (1) | 260 aa |
- Chen, C., Qin, Y., Xu, Y., Wang, X., Lei, W., Shen, X., Chen, L., Wang, L., Gong, J., Wang, Y., Hu, S., Liu, D. (2024) Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemia. Cardiovascular research. 120(9):1065-1080
- Lee, A., Kim, S.Y., Kang, S., Kang, S.H., Kim, D.W., Choe, J.W., Hyun, J.J., Jung, S.W., Jung, Y.K., Koo, J.S., Yim, H.J., Kim, S. (2024) Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae. International Journal of Molecular Sciences. 25(7):
- Paulissen, E., Martin, B.L. (2022) Myogenic regulatory factors myod and Myf5 are required for dorsal aorta formation and angiogenic sprouting. Developmental Biology. 490:134-143
- Vignes, H., Vagena-Pantoula, C., Prakash, M., Fukui, H., Norden, C., Mochizuki, N., Jug, F., Vermot, J. (2022) Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis. Developmental Cell. 57(5):598-609.e5
- Wang, S., Qin, Y., Sheng, J., Duan, X., Shen, L., Liu, D. (2022) Aquaporin 8ab is required in zebrafish embryonic intestine development. Acta biochimica et biophysica Sinica. 54:1-9
- Metikala, S., Casie Chetty, S., Sumanas, S. (2021) Single-cell transcriptome analysis of the zebrafish embryonic trunk. PLoS One. 16:e0254024
- Wierson, W.A., Welker, J.M., Almeida, M.P., Mann, C.M., Webster, D.A., Torrie, M.E., Weiss, T.J., Kambakam, S., Vollbrecht, M.K., Lan, M., McKeighan, K.C., Levey, J., Ming, Z., Wehmeier, A., Mikelson, C.S., Haltom, J.A., Kwan, K.M., Chien, C.B., Balciunas, D., Ekker, S.C., Clark, K.J., Webber, B.R., Moriarity, B.S., Solin, S.L., Carlson, D.F., Dobbs, D.L., McGrail, M., Essner, J. (2020) Efficient targeted integration directed by short homology in zebrafish and mammalian cells. eLIFE. 9:
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Chetty, S.C., Rost, M.S., Enriquez, J.R., Schumacher, J.A., Baltrunaite, K., Rossi, A., Stainier, D.Y., Sumanas, S. (2017) Vegf Signaling Promotes Vascular Endothelial Differentiation by Modulating etv2 Expression. Developmental Biology. 424(2):147-161
- Dong, C., Chen, L., Feng, J., Xu, J., Mahboob, S., Al-Ghanim, K., Li, X., Xu, P. (2016) Genome Wide Identification, Phylogeny, and Expression of Aquaporin Genes in Common Carp (Cyprinus carpio). PLoS One. 11:e0166160
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