Gene

epb41l3a

ID

ZDB-GENE-040822-8

Name

erythrocyte membrane protein band 4.1-like 3a

Symbol

epb41l3a Nomenclature History

Previous Names

zgc:92004
zmp:0000000522 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to enable actin binding activity and structural molecule activity. Acts upstream of or within regulation of excitatory synapse assembly. Predicted to be active in cytoskeleton and plasma membrane. Is expressed in nervous system; optic cup; and trigeminal placode. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human EPB41L3 (erythrocyte membrane protein band 4.1 like 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7152107 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Fierro et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With epb41l3a Human Ortholog

No data available

Associated With epb41l3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019747	FERM conserved site
Domain	IPR000299	FERM domain
Domain	IPR007477	SAB domain
Domain	IPR008379	Band 4.1, C-terminal
Domain	IPR014847	FERM adjacent
Domain	IPR018979	FERM, N-terminal
Domain	IPR018980	FERM, C-terminal PH-like domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR030691	Band 4.1-like protein 3, FERM domain, F1 sub-domain
Family	IPR000798	Ezrin/radixin/moesin-like
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain

Domain Details Per Protein

Protein	Length	Band 4.1, C-terminal	Band 4.1 domain	Band 4.1-like protein 3, FERM domain, F1 sub-domain	Ezrin/radixin/moesin-like	FERM/acyl-CoA-binding protein superfamily	FERM adjacent	FERM central domain	FERM conserved site	FERM, C-terminal PH-like domain	FERM domain	FERM, N-terminal	FERM superfamily, second domain	PH-like domain superfamily	SAB domain	Ubiquitin-like domain superfamily
UniProtKB:A0A8M9PFY0 InterPro	1073
UniProtKB:A0A8M9P5U6 InterPro	1088
UniProtKB:Q68EI5 InterPro	826
UniProtKB:A0A8M9PLP9 InterPro	1053
UniProtKB:A0A8M9P5V2 InterPro	903
UniProtKB:A0A8M9PU07 InterPro	937
UniProtKB:A0A8M9PFZ0 InterPro	861
UniProtKB:A0A8M9PXF8 InterPro	735
UniProtKB:A0A8M9PXF4 InterPro	972
UniProtKB:A0A8M9P5U9 InterPro	1177

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	epb41l3a-201 (1) Ensembl	Ensembl		3,052 nt	Select Tool ZFIN BLAST
mRNA	epb41l3a-202 (1) Ensembl	Ensembl		3,344 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations