Gene
kras
- ID
- ZDB-GENE-040808-67
- Name
- v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
- Symbol
- kras Nomenclature History
- Previous Names
-
- fa04e08
- fc14b12
- fc23g10
- fj89d12
- wu:fa04e08
- wu:fc14b12
- wu:fc23g10
- wu:fj89d12
- xRAS2 (1)
- zgc:85725
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have GDP binding activity; GTP binding activity; and GTPase activity. Involved in embryonic cranial skeleton morphogenesis; heart development; and hemopoiesis. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is expressed in brain; heart; liver; pleuroperitoneal region; and trunk musculature. Orthologous to human KRAS (KRAS proto-oncogene, GTPase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Liu et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
| arteriovenous malformations of the brain | Alliance | Arteriovenous malformation of the brain, somatic | 108010 |
| autoimmune lymphoproliferative syndrome type 4 | Alliance | RAS-associated autoimmune leukoproliferative disorder | 614470 |
| breast cancer | Alliance | Breast cancer, somatic | 114480 |
| cardiofaciocutaneous syndrome 2 | Alliance | Cardiofaciocutaneous syndrome 2 | 615278 |
| linear nevus sebaceous syndrome | Alliance | Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic | 163200 |
| lung cancer | Alliance | Lung cancer, somatic | 211980 |
| Noonan syndrome 3 | Alliance | Noonan syndrome 3 | 609942 |
| oculoectodermal syndrome | Alliance | Oculoectodermal syndrome, somatic | 600268 |
| pancreatic carcinoma | Alliance | Pancreatic carcinoma, somatic | 260350 |
| stomach cancer | Alliance | Gastric cancer, somatic | 613659 |
| urinary bladder cancer | Alliance | Bladder cancer, somatic | 109800 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase, Ras-type | Small GTP-binding domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A2R8Q8S1
|
189 | ||||
|
UniProtKB:Q6AZA4
|
188 |
- Genome Browsers
Interactions and Pathways
Plasmids
No data available