Gene
hpdb
- ID
- ZDB-GENE-040808-62
- Name
- 4-hydroxyphenylpyruvate dioxygenase b
- Symbol
- hpdb Nomenclature History
- Previous Names
-
- hpd
- zgc:92456
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to act upstream of or within aromatic amino acid metabolic process. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and membrane. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including ectoderm; epidermis; median fin fold; neurons; and otic vesicle. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92456 (10 images)
- IMAGE:7162729 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hawkinsinuria | Alliance | Hawkinsinuria | 140350 |
| tyrosinemia type III | Alliance | Tyrosinemia, type III | 276710 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004360 | Glyoxalase/fosfomycin resistance/dioxygenase domain |
| Domain | IPR037523 | Vicinal oxygen chelate (VOC) domain |
| Domain | IPR041735 | 4-hydroxyphenylpyruvate dioxygenase, C-terminal |
| Domain | IPR041736 | 4-hydroxyphenylpyruvate dioxygenase, N-terminal |
| Family | IPR005956 | 4-hydroxyphenylpyruvate dioxygenase |
| Homologous_superfamily | IPR029068 | Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase |
Domain Details Per Protein
| Protein | Length | 4-hydroxyphenylpyruvate dioxygenase | 4-hydroxyphenylpyruvate dioxygenase, C-terminal | 4-hydroxyphenylpyruvate dioxygenase, N-terminal | Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | Glyoxalase/fosfomycin resistance/dioxygenase domain | Vicinal oxygen chelate (VOC) domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6AZV8
|
393 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available