Gene

nrros

ID

ZDB-GENE-040808-36

Name

negative regulator of reactive oxygen species

Symbol

nrros Nomenclature History

Previous Names

lrrc33
zgc:100989

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to enable growth factor binding activity. Predicted to be involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in extracellular matrix and extracellular space. Is expressed in hematopoietic cell; intermediate cell mass of mesoderm; vein; and ventral mesoderm. Orthologous to human NRROS (negative regulator of reactive oxygen species).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7148958 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nrros Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Seizures, early-onset, with neurodegeneration and brain calcification	618875

Associated With nrros Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR050328	Multifunctional Developmental and Immune Receptor
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype
Repeat	IPR026906	BspA-type LRR region