Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040805-1
Gene Name: B-Raf proto-oncogene, serine/threonine kinase
Gene Symbol: braf
Location: Chr: 4   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu590]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
  whole organism
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa20230, sa20231, sa20232
Knockdown reagents: MO1-braf (1)
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Adenocarcinoma of lung, somatic 211980
Cardiofaciocutaneous syndrome 115150
Colorectal cancer, somatic
LEOPARD syndrome 3 613707
Melanoma, malignant, somatic
Nonsmall cell lung cancer, somatic
Noonan syndrome 7 613706
GENE ONTOLOGY
Ontology GO Term
Biological Process intracellular signal transduction (more)
Molecular Function ATP binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002219 (1)
  • InterPro:IPR003116 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020454 (1)
  • InterPro:IPR029071 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS00479 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50081 (1)
  • PROSITE:PS50898 (1)
  • Pfam:PF00130 (1)
  • Pfam:PF02196 (1)
  • Pfam:PF07714 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA braf-001 (1) 2613
    ncRNA braf-002 (1) 1818
    mRNA braf-003 (1) 2986
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM braf No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    braf Contained in: [BAC] DKEY-222F8 (1)
    braf Encodes: [EST] eu590 (1)
    [cDNA] MGC:193731 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205744 (1) 2629 bp
    Genomic GenBank:BX005210 (1) 207949 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q1LYG2 (1) 817 aa
    Sequence Clusters UniGene:108603 (1)
    Sequence Information (all 29)
    OTHER braf GENE PAGES
  • Gene:403065 (1)
  • VEGA:OTTDARG00000007629 (1)
  • Ensembl(Zv9):ENSDARG00000017661 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish braf 4  
    Human BRAF 7 (7q34)
  • OMIM:164757
  • Gene:673
  • Mouse Braf 6 ( 18.43 cM)
  • MGI:88190
  • Gene:109880
  • Orthology Details
    CITATIONS (23)