ZFIN ID: ZDB-GENE-040805-1
Gene Name: B-Raf proto-oncogene, serine/threonine kinase
Gene Symbol: braf

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Location: Chr: 4 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu590]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
  whole organism
PHENOTYPE No data available
DISEASE ASSOCIATED WITH braf HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
cardiofaciocutaneous syndrome Cardiofaciocutaneous syndrome 115150
LEOPARD syndrome LEOPARD syndrome 3 613707
lung cancer Adenocarcinoma of lung, somatic 211980
Noonan syndrome 7 Noonan syndrome 7 613706
Nonsmall cell lung cancer, somatic
Melanoma, malignant, somatic
Colorectal cancer, somatic
GENE ONTOLOGY
Ontology GO Term
Biological Process intracellular signal transduction (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 23)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002219 (1)
  • InterPro:IPR003116 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020454 (1)
  • InterPro:IPR029071 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS00479 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50081 (1)
  • PROSITE:PS50898 (1)
  • Pfam:PF00130 (1)
  • Pfam:PF02196 (1)
  • Pfam:PF07714 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA braf-001 (1) 2613
    ncRNA braf-002 (1) 1818
    mRNA braf-003 (1) 2986
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM braf No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    brafContained in: [BAC] DKEY-222F8 (1) (order this)
    brafEncodes: [EST] eu590 (1)
    [cDNA] MGC:193731 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001324516 (1) 5352bp
    Genomic GenBank:BX005210 (1) 207949bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q1LYG2 (1) 817aa
    Sequence Clusters UniGene:108603 (1)
    Sequence Information (all 29)
    OTHER braf GENE PAGES
  • Gene:403065 (1)
  • VEGA:OTTDARG00000007629 (1)
  • Ensembl(GRCz10):ENSDARG00000017661 (1)
  • ORTHOLOGY for braf (Chr: 4)
    CITATIONS (25)