ZFIN ID: ZDB-GENE-040805-1
Gene Name: B-Raf proto-oncogene, serine/threonine kinase
Gene Symbol: braf
Location: Chr: 4   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu590]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
  whole organism
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
sa20230 Point Mutation ENU
sa20231 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa20232 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-braf (1)
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH braf HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    lung cancer Adenocarcinoma of lung, somatic 211980
    cardiofaciocutaneous syndrome Cardiofaciocutaneous syndrome 115150
    LEOPARD syndrome LEOPARD syndrome 3 613707
    Noonan syndrome Noonan syndrome 7 613706
    Colorectal cancer, somatic
    Melanoma, malignant, somatic
    Nonsmall cell lung cancer, somatic
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular signal transduction (more)
    Molecular Function ATP binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002219 (1)
  • InterPro:IPR003116 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020454 (1)
  • InterPro:IPR029071 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS00479 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50081 (1)
  • PROSITE:PS50898 (1)
  • Pfam:PF00130 (1)
  • Pfam:PF02196 (1)
  • Pfam:PF07714 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA braf-001 (1) 2613
    ncRNA braf-002 (1) 1818
    mRNA braf-003 (1) 2986
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM braf No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    braf Contained in: [BAC] DKEY-222F8 (1) (order this)
    braf Encodes: [EST] eu590 (1)
    [cDNA] MGC:193731 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205744 (1) 2629 bp
    Genomic GenBank:BX005210 (1) 207949 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q1LYG2 (1) 817 aa
    Sequence Clusters UniGene:108603 (1)
    Sequence Information (all 29)
    OTHER braf GENE PAGES
  • Gene:403065 (1)
  • VEGA:OTTDARG00000007629 (1)
  • Ensembl(Zv9):ENSDARG00000017661 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish braf 4  
    Human BRAF 7 (7q34)
  • OMIM:164757
  • Gene:673
  • Mouse Braf 6 ( 18.43 cM)
  • MGI:88190
  • Gene:109880
  • Orthology Details
    CITATIONS (23)