ZFIN ID: ZDB-GENE-040805-1
Gene Name: B-Raf proto-oncogene, serine/threonine kinase
Gene Symbol: braf
Location: Chr: 4 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu590]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
  whole organism
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20230 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20231 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa20232 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa40247 Point Mutation Unknown Unknown ENU
    Targeting reagents: MO1-braf (1)
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH braf HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    cardiofaciocutaneous syndrome Cardiofaciocutaneous syndrome 115150
    LEOPARD syndrome LEOPARD syndrome 3 613707
    lung cancer Adenocarcinoma of lung, somatic 211980
    Noonan syndrome Noonan syndrome 7 613706
    Colorectal cancer, somatic
    Nonsmall cell lung cancer, somatic
    Melanoma, malignant, somatic
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular signal transduction (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002219 (1)
  • InterPro:IPR003116 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020454 (1)
  • InterPro:IPR029071 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS00479 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50081 (1)
  • PROSITE:PS50898 (1)
  • Pfam:PF00130 (1)
  • Pfam:PF02196 (1)
  • Pfam:PF07714 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA braf-001 (1) 2613
    ncRNA braf-002 (1) 1818
    mRNA braf-003 (1) 2986
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM braf No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    brafContained in: [BAC] DKEY-222F8 (1) (order this)
    brafEncodes: [EST] eu590 (1)
    [cDNA] MGC:193731 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001324516 (1) 5352bp
    Genomic GenBank:BX005210 (1) 207949bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q1LYG2 (1) 817aa
    Sequence Clusters UniGene:108603 (1)
    Sequence Information (all 31)
    OTHER braf GENE PAGES
  • Gene:403065 (1)
  • VEGA:OTTDARG00000007629 (1)
  • Ensembl(GRCz10):ENSDARG00000017661 (1)
  • ORTHOLOGY for braf (Chr: 4)
    Species Symbol Chromosome Accession # Evidence
    Human BRAF 7
  • Gene:673
  • OMIM:164757
  • HGNC:1097
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse Braf 6
  • MGI:88190
  • Gene:109880
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (24)