Gene
hadh
- ID
- ZDB-GENE-040801-261
- Name
- hydroxyacyl-CoA dehydrogenase
- Symbol
- hadh Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in intestine and liver. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 4. Orthologous to human HADH (hydroxyacyl-CoA dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hyperinsulinemic hypoglycemia 4 | Alliance | Hyperinsulinemic hypoglycemia, familial, 4 | 609975 |
| 3-hydroxyacyl-CoA dehydrogenase deficiency | 231530 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR006180 | 3-hydroxyacyl-CoA dehydrogenase, conserved site |
| Domain | IPR006108 | 3-hydroxyacyl-CoA dehydrogenase, C-terminal |
| Domain | IPR006176 | 3-hydroxyacyl-CoA dehydrogenase, NAD binding |
| Family | IPR022694 | 3-hydroxyacyl-CoA dehydrogenase |
| Family | IPR052242 | Mitochondrial 3-hydroxyacyl-CoA dehydrogenase |
| Homologous_superfamily | IPR008927 | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily |
| Homologous_superfamily | IPR013328 | 6-phosphogluconate dehydrogenase, domain 2 |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 3-hydroxyacyl-CoA dehydrogenase | 3-hydroxyacyl-CoA dehydrogenase, conserved site | 3-hydroxyacyl-CoA dehydrogenase, C-terminal | 3-hydroxyacyl-CoA dehydrogenase, NAD binding | 6-phosphogluconate dehydrogenase, domain 2 | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily | Mitochondrial 3-hydroxyacyl-CoA dehydrogenase | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DI22 | InterPro | 309 |
Interactions and Pathways
No data available
Plasmids
No data available