Gene
alkbh3
- ID
- ZDB-GENE-040801-254
- Name
- alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
- Symbol
- alkbh3 Nomenclature History
- Previous Names
-
- im:6900103
- zgc:91935 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable mRNA N1-methyladenosine dioxygenase activity. Acts upstream of or within cilium assembly. Predicted to be active in mitochondrion and nucleoplasm. Is expressed in brain. Orthologous to human ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6900103 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Kuang et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005123 | Oxoglutarate/iron-dependent dioxygenase domain |
| Domain | IPR027450 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
| Family | IPR032854 | Alkylated DNA repair protein alkB homologue 3 |
| Homologous_superfamily | IPR037151 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily |
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Domain Details Per Protein
| Protein | Length | Alkylated DNA repair protein alkB homologue 3 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily | Oxoglutarate/iron-dependent dioxygenase domain |
|---|---|---|---|---|---|
|
UniProtKB:F1QRD8
|
|||||
|
UniProtKB:A0A8M2BAA9
|
236 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
alkbh3-201
(1)
|
Ensembl | 1,475 nt | ||
| mRNA |
alkbh3-202
(1)
|
Ensembl | 1,209 nt | ||
| mRNA |
alkbh3-203
(1)
|
Ensembl | 778 nt | ||
| mRNA |
alkbh3-204
(1)
|
Ensembl | 541 nt | ||
| mRNA |
alkbh3-205
(1)
|
Ensembl | 423 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-147K10 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6900103 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:91935 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003511 (1) | 1257 nt | ||
| Genomic | GenBank:CR376745 (1) | 186587 nt | ||
| Polypeptide | UniProtKB:A0A8M2BAA9 (1) | 236 aa |
- Kuang, W., Jin, H., Yang, F., Chen, X., Liu, J., Li, T., Chang, Y., Liu, M., Xu, Z., Huo, C., Yan, X., Yang, Y., Liu, W., Shu, Q., Xie, S., Zhou, T. (2022) ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis. Cell discovery. 8:25
- Sun, Q., Liu, X., Gong, B., Wu, D., Meng, A., Jia, S. (2017) Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly. International journal of biological sciences. 13:1051-1066
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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