Gene

prkacab

ID

ZDB-GENE-040801-208

Name

protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b

Symbol

prkacab Nomenclature History

Previous Names

zgc:91856

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable cAMP-dependent protein kinase activity and protein kinase A regulatory subunit binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in mitochondrion and plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; fin bud; optic cup; pronephric duct; and retinal neural layer. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease 4. Orthologous to several human genes including PRKACA (protein kinase cAMP-activated catalytic subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:91856 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkacab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary pigmented nodular adrenocortical disease 4	Alliance	Cushing syndrome, ACTH-independent adrenal, somatic	615830
		Cardioacrofacial dysplasia 1	619142

Associated With prkacab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Family	IPR044109	cAMP-dependent protein kinase catalytic subunit
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily