Gene

rorcb

ID

ZDB-GENE-040724-215

Name

RAR-related orphan receptor C b

Symbol

rorcb Nomenclature History

Previous Names

NR1F3-B (1)
RORgamma-B (1)
RORgamma2 (1)
si:ch211-168n16.2
si:dkey-158a20.2

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have several functions, including nuclear receptor activity; steroid hormone receptor activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in intestinal bulb; nervous system; and presumptive diencephalon. Orthologous to human RORC (RAR related orphan receptor C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

dq017628 (21 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rorcb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 42	Alliance	Immunodeficiency 42	616622

Associated With rorcb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000536	Nuclear hormone receptor, ligand-binding domain
Domain	IPR001628	Zinc finger, nuclear hormone receptor-type
Domain	IPR044101	Retinoid-related orphan receptors, DNA-binding domain
Family	IPR001723	Nuclear hormone receptor
Family	IPR003079	Nuclear receptor ROR
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type
Homologous_superfamily	IPR035500	Nuclear hormone receptor-like domain superfamily