Gene
kcnk3a
- ID
- ZDB-GENE-040724-171
- Name
- potassium channel, subfamily K, member 3a
- Symbol
- kcnk3a Nomenclature History
- Previous Names
-
- kcnk3
- si:dkey-164m15.1
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Acts upstream of or within heart contraction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in atrium; cardiac ventricle; central nervous system; and heart. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human KCNK3 (potassium two pore domain channel subfamily K member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa39272 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-kcnk3a | N/A | Liang et al., 2014 |
| MO2-kcnk3a | N/A | Liang et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary pulmonary hypertension | Alliance | Pulmonary hypertension, primary, 4 | 615344 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Potassium channel domain | Potassium channel subfamily K member 3 | Two pore domain potassium channel | Two pore domain potassium channel, TASK family |
|---|---|---|---|---|---|
|
UniProtKB:Q5TZ59
|
390 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnk3a-201
(1)
|
Ensembl | 1,173 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-164M15 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030162 (1) | 1173 nt | ||
| Genomic | GenBank:BX470123 (1) | 82855 nt | ||
| Polypeptide | UniProtKB:Q5TZ59 (1) | 390 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Wen, Z.Y., Wang, J., Bian, C., Zhang, X., Li, J., Peng, Y., Zhan, Q., Shi, Q., Li, Y.Y. (2019) Molecular cloning of two kcnk3 genes from the Northern snakehead (Channa argus) for quantification of their transcriptions in response to fasting and refeeding. General and comparative endocrinology. 281:49-57
- Skarsfeldt, M.A., Bomholtz, S.H., Lundegaard, P.R., Lopez-Izquierdo, A., Tristani-Firouzi, M., Bentzen, B.H. (2018) Atrium-specific ion channels in the zebrafish-A role of IKACh in atrial repolarization.. Acta physiologica (Oxford, England). 223(3):e13049
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Liang, B., Soka, M., Christensen, A.H., Olesen, M.S., Larsen, A.P., Knop, F.K., Wang, F., Nielsen, J.B., Andersen, M.N., Humphreys, D., Mann, S.A., Huttner, I.G., Vandenberg, J.I., Svendsen, J.H., Haunsø, S., Preiss, T., Seebohm, G., Olesen, S.P., Schmitt, N., and Fatkin, D. (2014) Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis. Journal of Molecular and Cellular Cardiology. 67:69-76
- Gierten, J., Hassel, D., Schweizer, P.A., Becker, R., Katus, H.A., and Thomas, D. (2012) Identification and functional characterization of zebrafish K2P10.1 (TREK2) two-pore-domain K+ channels. Biomembranes. 1818(1):33-41
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