Gene
oxct1a
- ID
- ZDB-GENE-040723-3
- Name
- 3-oxoacid CoA transferase 1a
- Symbol
- oxct1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable succinyl-CoA:3-oxo-acid CoA-transferase activity. Predicted to be involved in ketone body metabolic process. Predicted to act upstream of or within ketone body catabolic process. Predicted to be active in mitochondrion. Is expressed in somite. Orthologous to several human genes including OXCT1 (3-oxoacid CoA-transferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from Rauch et al., 2003
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| nksagm018bGt | Transgenic insertion | Unknown | Unknown | DNA | |
| sa45329 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Succinyl CoA:3-oxoacid CoA transferase deficiency | 245050 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR004164 | Coenzyme A transferase active site |
| Binding_site | IPR004163 | Coenzyme A transferase binding site |
| Domain | IPR012791 | 3-oxoacid CoA-transferase, subunit B |
| Domain | IPR012792 | 3-oxoacid CoA-transferase, subunit A |
| Family | IPR004165 | Coenzyme A transferase family I |
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Domain Details Per Protein
| Protein | Length | 3-oxoacid CoA-transferase | 3-oxoacid CoA-transferase, subunit A | 3-oxoacid CoA-transferase, subunit B | Coenzyme A transferase active site | Coenzyme A transferase binding site | Coenzyme A transferase family I | NagB/RpiA transferase-like |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6AZB2
|
525 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
oxct1a-201
(1)
|
Ensembl | 2,666 nt | ||
| mRNA |
oxct1a-203
(1)
|
Ensembl | 830 nt | ||
| mRNA |
oxct1a-204
(1)
|
Ensembl | 719 nt | ||
| mRNA |
oxct1a-205
(1)
|
Ensembl | 2,131 nt | ||
| ncRNA |
oxct1a-002
(1)
|
Ensembl | 492 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-46A10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-174D5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-250L23 | ZFIN Curated Data | |
| Encodes | EST | fc10c02 | Rauch et al., 2003 | |
| Encodes | EST | fj36f06 | ||
| Encodes | EST | fj48g08 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92003 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191147 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007291 (1) | 2109 nt | ||
| Genomic | GenBank:BX571721 (1) | 168402 nt | ||
| Polypeptide | UniProtKB:Q6AZB2 (1) | 525 aa |
- Zhang, J., Qian, L., Wang, C., Teng, M., Duan, M., Chen, X., Li, X., Wang, C. (2020) UPLC-TOF-MS/MS metabolomics analysis of zebrafish metabolism by spirotetramat. Environmental pollution (Barking, Essex : 1987). 266:115310
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kotani, T., and Kawakami, K. (2008) misty somites, a maternal effect gene identified by transposon-mediated insertional mutagenesis in zebrafish that is essential for the somite boundary maintenance. Developmental Biology. 316(2):383-396
- Fukamachi, S., and Meyer, A. (2007) Evolution of receptors for growth hormone and somatolactin in fish and land vertebrates: lessons from the lungfish and sturgeon orthologues. Journal of molecular evolution. 65(4):359-372
- Liongue, C., and Ward, A.C. (2007) Evolution of Class I cytokine receptors. BMC Evolutionary Biology. 7(1):120
- Kotani, T., Nagayoshi, S., Urasaki, A., and Kawakami, K. (2006) Transposon-mediated gene trapping in zebrafish. Methods (San Diego, Calif.). 39(3):199-206
- Kawakami, K., Takeda, H., Kawakami, N., Kobayashi, M., Matsuda, N., and Mishina, M. (2004) A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish. Developmental Cell. 7(1):133-144
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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