Gene

tnni2a.3

ID

ZDB-GENE-040718-80

Name

troponin I type 2a (skeletal, fast), tandem duplicate 3

Symbol

tnni2a.3 Nomenclature History

Previous Names

tropI-1c (1)
zgc:92053

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to be involved in cardiac muscle contraction and skeletal muscle contraction. Predicted to localize to troponin complex. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B1 and intrinsic cardiomyopathy (multiple). Is expressed in muscle; musculature system; myotome; and pectoral fin musculature. Orthologous to several human genes including TNNI2 (troponin I2, fast skeletal type).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92053 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnni2a.3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
distal arthrogryposis type 2B1	Alliance	Arthrogryposis, distal, type 2B1	601680

Associated With tnni2a.3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001978	Troponin
Family	IPR050875	Troponin I
Homologous_superfamily	IPR038077	Troponin domain superfamily

Domain Details Per Protein

Protein	Length	Troponin	Troponin domain superfamily	Troponin I
UniProtKB:Q6DHU6 InterPro	176

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tnni2a.3-201 (1) Ensembl	Ensembl		1,522 nt	Select Tool
mRNA	tnni2a.3-202 (1) Ensembl	Ensembl		916 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: tnni2a.1, tnni2a.2, tnni2a.3, and tnni2a.4 form a cluster on chromosome 25 and are likely the result of tandem duplications. The location of the cluster in zebrafish as well as the amino acid identity of all genes in the cluster support orthology to human TNNI2 and mouse Tnni2.

Citations