Gene
gata2b
- ID
- ZDB-GENE-040718-440
- Name
- GATA binding protein 2b
- Symbol
- gata2b Nomenclature History
- Previous Names
-
- zgc:91840 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in definitive hemopoiesis and hematopoietic stem cell differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; mental depression; myelodysplastic syndrome; myeloid leukemia; and primary immunodeficiency disease. Is expressed in several structures, including dorsal aorta; hematopoietic cell; hematopoietic system; neurons; and vascular cord. Orthologous to human GATA2 (GATA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91840 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | {Leukemia, acute myeloid, susceptibility to} | 601626 |
| immunodeficiency 21 | Alliance | Immunodeficiency 21 | 614172 |
| myelodysplastic syndrome | Alliance | {Myelodysplastic syndrome, susceptibility to} | 614286 |
| Emberger syndrome | 614038 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Transcription factor GATA | Transcription factor, GATA-2/3 | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|
|
UniProtKB:F1QD30
|
428 | ||||
|
UniProtKB:Q6DG89
|
427 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gata2b-201
(1)
|
Ensembl | 1,955 nt |
Interactions and Pathways
No data available
Plasmids