Gene
sec63
- ID
- ZDB-GENE-040718-328
- Name
- SEC63 homolog, protein translocation regulator
- Symbol
- sec63 Nomenclature History
- Previous Names
-
- zgc:92718
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable protein transmembrane transporter activity. Acts upstream of or within endoplasmic reticulum unfolded protein response; liver development; and myelination. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of Sec62/Sec63 complex. Used to study polycystic liver disease and steatotic liver disease. Human ortholog(s) of this gene implicated in polycystic liver disease 2. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151132 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| polycystic liver disease 2 | Alliance | Polycystic liver disease 2 | 617004 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| steatotic liver disease | sec63st67/st67 | standard conditions | (2) |
| polycystic liver disease | WT + MO1-sec63 | standard conditions | Tietz Bogert et al., 2013 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | C2 domain superfamily | Chaperone J-domain superfamily | DnaJ domain | Immunoglobulin E-set | Sec63 domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6DGY6
|
751 |
Interactions and Pathways
No data available
Plasmids
No data available