Gene

sec63

ID
ZDB-GENE-040718-328
Name
SEC63 homolog, protein translocation regulator
Symbol
sec63 Nomenclature History
Previous Names
  • zgc:92718
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable protein transmembrane transporter activity. Acts upstream of or within endoplasmic reticulum unfolded protein response; liver development; and myelination. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of Sec62/Sec63 complex. Used to study polycystic liver disease and steatotic liver disease. Human ortholog(s) of this gene implicated in polycystic liver disease 2. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa12378Allele with one point mutationUnknownPremature StopENU
sa37078Allele with one point mutationUnknownPremature StopENU
st67Allele with one point mutationUnknownMissenseENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-sec63N/A (2)
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Human Disease
Associated With sec63 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
polycystic liver disease 2 Alliance Polycystic liver disease 2 617004
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Associated With sec63 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001623 DnaJ domain
Domain IPR004179 Sec63 domain
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR036869 Chaperone J-domain superfamily
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Domain Details Per Protein
Protein Length C2 domain superfamily Chaperone J-domain superfamily DnaJ domain Immunoglobulin E-set Sec63 domain
UniProtKB:Q6DGY6 751
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 20
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA sec63-201 (1) Ensembl 4,207 nt
mRNA sec63-204 (1) Ensembl 4,207 nt
ncRNA sec63-002 (1) Ensembl 601 nt
ncRNA sec63-003 (1) Ensembl 753 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-257C13ZFIN Curated Data
Contained inFosmidCH1073-83O12ZFIN Curated Data
Contained inFosmidCH1073-108O16ZFIN Curated Data
EncodesESTIMAGE:7151132Thisse et al., 2004
EncodescDNAMGC:92718ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSEC636
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
MouseSec6310
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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