Gene
sec63
- ID
- ZDB-GENE-040718-328
- Name
- SEC63 homolog, protein translocation regulator
- Symbol
- sec63 Nomenclature History
- Previous Names
-
- zgc:92718
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable protein transmembrane transporter activity. Acts upstream of or within endoplasmic reticulum unfolded protein response; liver development; and myelination. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of Sec62/Sec63 complex. Used to study polycystic liver disease and steatotic liver disease. Human ortholog(s) of this gene implicated in polycystic liver disease 2. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151132 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| polycystic liver disease 2 | Alliance | Polycystic liver disease 2 | 617004 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| steatotic liver disease | sec63st67/st67 | standard conditions | (2) |
| polycystic liver disease | WT + MO1-sec63 | standard conditions | Tietz Bogert et al., 2013 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | C2 domain superfamily | Chaperone J-domain superfamily | DnaJ domain | Immunoglobulin E-set | Sec63 domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6DGY6
|
751 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-257C13 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-83O12 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-108O16 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7151132 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92718 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002588 (1) | 2690 nt | ||
| Genomic | GenBank:CU207298 (2) | 34410 nt | ||
| Polypeptide | UniProtKB:Q6DGY6 (1) | 751 aa |
- Wang, D., Weng, Y., Guo, S., Qin, W., Ni, J., Yu, L., Zhang, Y., Zhao, Q., Ben, J., Ma, J. (2019) microRNA-1 Regulates NCC Migration and Differentiation by Targeting sec63. International journal of biological sciences. 15:2538-2547
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Asaoka, Y., Terai, S., Sakaida, I., and Nishina, H. (2013) The expanding role of fish models in understanding non-alcoholic fatty liver disease. Disease models & mechanisms. 6(4):905-914
- Monk, K.R., Voas, M.G., Franzini-Armstrong, C., Hakkinen, I.S., and Talbot, W.S. (2013) Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology. Disease models & mechanisms. 6(1):135-145
- Tietz Bogert, P.S., Huang, B.Q., Gradilone, S.A., Masyuk, T.V., Moulder, G.L., Ekker, S.C., and Larusso, N.F. (2013) The zebrafish as a model to study polycystic liver disease. Zebrafish. 10(2):211-217
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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