Gene
dnase1l1l
- ID
- ZDB-GENE-040718-100
- Name
- deoxyribonuclease I-like 1-like
- Symbol
- dnase1l1l Nomenclature History
- Previous Names
-
- dnase1l3l
- zgc:92699
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and deoxyribonuclease I activity. Acts upstream of or within lens fiber cell differentiation and retina development in camera-type eye. Predicted to be active in nucleus. Is expressed in eye; lens; lens epithelium; and solid lens vesicle.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139511 (5 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dnase1l1l | Zhang et al., 2020 | |
| MO1-dnase1l1l | N/A | Iida et al., 2014 |
| MO2-dnase1l1l | N/A | Iida et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Deoxyribonuclease I | Endonuclease/exonuclease/phosphatase | Endonuclease/exonuclease/phosphatase superfamily |
|---|---|---|---|---|
|
UniProtKB:Q6DH05
|
292 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dnase1l1l-201
(1)
|
Ensembl | 1,215 nt | ||
| mRNA |
dnase1l1l-202
(1)
|
Ensembl | 2,649 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-183P4 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7139511 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92699 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002403 (1) | 1112 nt | ||
| Genomic | GenBank:CR847543 (1) | 207382 nt | ||
| Polypeptide | UniProtKB:Q6DH05 (1) | 292 aa |
No data available
- Zhang, J., Cui, W.W., Du, C., Huang, Y., Pi, X., Guo, W., Wang, J., Huang, W., Chen, D., Li, J., Li, H., Zhang, J., Ma, Y., Mu, H., Zhang, S., Liu, M., Cui, X., Hu, Y. (2020) Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1866:165724
- Iida, A., Tabata, Y., Baba, Y., Fujii, T., Watanabe, S. (2014) Critical roles of DNase1l3l in lens nuclear degeneration in zebrafish. Biochimie. 106:68-74
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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