Gene
htra1a
- ID
- ZDB-GENE-040704-64
- Name
- HtrA serine peptidase 1a
- Symbol
- htra1a Nomenclature History
- Previous Names
-
- htra1
- zgc:92029
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have insulin-like growth factor binding activity and serine-type endopeptidase activity. Involved in regulation of fibroblast growth factor receptor signaling pathway. Predicted to localize to cytosol and extracellular region. Human ortholog(s) of this gene implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple). Is expressed in mesoderm and somite. Orthologous to human HTRA1 (HtrA serine peptidase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92029 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Kim et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 7 | Alliance | {Macular degeneration, age-related, 7} | 610149 |
| age related macular degeneration 7 | Alliance | {Macular degeneration, age-related, neovascular type} | 610149 |
| CADASIL | Alliance | CARASIL syndrome | 600142 |
| CADASIL 2 | Alliance | Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 | 616779 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR002350 | Kazal domain |
| Domain | IPR041489 | PDZ domain 6 |
| Family | IPR001940 | Peptidase S1C |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036058 | Kazal domain superfamily |
Domain Details Per Protein
| Protein | Length | Growth factor receptor cysteine-rich domain superfamily | Insulin-like growth factor-binding protein, IGFBP | Kazal domain | Kazal domain superfamily | PDZ domain | PDZ domain 6 | PDZ superfamily | Peptidase S1C | Peptidase S1, PA clan |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6GMI0
|
479 | |||||||||
|
UniProtKB:B2GT42
|
479 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
htra1a-201
(1)
|
Havana | 2078 nt |
Interactions and Pathways
No data available
Plasmids
No data available