Gene

rac2

ID
ZDB-GENE-040625-27
Name
Rac family small GTPase 2
Symbol
rac2 Nomenclature History
Previous Names
  • zgc:86686
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including defense response to other organism; leukocyte chemotaxis; and regulation of neutrophil migration. Localizes to cytoplasm. Is expressed in neutrophil and thymus. Orthologous to human RAC2 (Rac family small GTPase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rac2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis Alliance Immunodeficiency 73A with defective neutrophil chemotaxix and leukocytosis 608203
immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia Alliance Immunodeficiency 73B with defective neutrophil chemotaxis and lymphopenia 618986
immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia Alliance ?Immunodeficiency 73C with defective neutrophil chemotaxis and hypogammaglobulinemia 618987
Associated With rac2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005225 Small GTP-binding protein domain
Family IPR001806 Small GTPase
Family IPR003578 Small GTPase Rho
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length P-loop containing nucleoside triphosphate hydrolase Small GTPase Small GTPase Rho Small GTP-binding protein domain
UniProtKB:Q6IQN5 192
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-rac2 polyclonal Rabbit
  • IHC
Santa Cruz Biotechnology, Inc.
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations