Gene

sae1

ID

ZDB-GENE-040625-21

Name

SUMO1 activating enzyme subunit 1

Symbol

sae1 Nomenclature History

Previous Names

fa28b04
sae2a (1)
uble1a (1)
wu:fa28b04 (1)
zgc:86633

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable SUMO activating enzyme activity and protein C-terminus binding activity. Acts upstream of or within definitive hemopoiesis; hematopoietic stem cell homeostasis; and protein sumoylation. Predicted to be located in nucleus. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Is expressed in brain. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6910490 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sae1 Human Ortholog

No data available

Associated With sae1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000594	THIF-type NAD/FAD binding fold
Family	IPR000011	Ubiquitin/SUMO-activating enzyme E1-like
Family	IPR045886	ThiF/MoeB/HesA family
Homologous_superfamily	IPR035985	Ubiquitin-activating enzyme