Gene
irs2a
- ID
- ZDB-GENE-040426-975
- Name
- insulin receptor substrate 2a
- Symbol
- irs2a Nomenclature History
- Previous Names
-
- zgc:56306
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Acts upstream of or within response to hypoxia. Predicted to be active in cytosol and plasma membrane. Is expressed in germ ring; head; and liver. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-irs2a | China Zebrafish Resource Center (CZRC) | |
| MO1-irs2a | N/A | (2) |
| MO2-irs2a | N/A | Fukushima et al., 2015 |
| MO3-irs2a | N/A | Zasu et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent} | 125853 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Insulin receptor substrate | IRS-type PTB domain | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PD89
|
1086 | ||||
|
UniProtKB:Q7ZU74
|
1032 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198K9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56306 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200315 (1) | 4194 nt | ||
| Genomic | GenBank:BX908780 (2) | 199679 nt | ||
| Polypeptide | UniProtKB:A0A8M9PD89 (1) | 1086 aa |
- Ulhaq, Z.S., Tse, W.K.F. (2024) PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease. Genes. 15(1):
- Yu, W., Luo, R., He, C., Li, Z., Yang, M., Zhou, J., He, J., Chen, Q., Song, Z., Cheng, S. (2024) Bergenin mitigates neuroinflammatory damage induced by high glucose: insights from Zebrafish, murine microbial cell line, and rat models. Frontiers in pharmacology. 15:13391781339178
- He, T., Lykov, N., Luo, X., Wang, H., Du, Z., Chen, Z., Chen, S., Zhu, L., Zhao, Y., Tzeng, C. (2023) Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. International Journal of Molecular Sciences. 24(3):
- Li, X., Zhou, L., Zheng, Y., He, T., Guo, H., Li, J., Zhang, J. (2023) Establishment of a non-alcoholic fatty liver disease model by high fat diet in adult zebrafish. Animal models and experimental medicine. 7(6):904-913
- Medkova, D., Hollerova, A., Blahova, J., Marsalek, P., Mares, J., Hodkovicova, N., Doubkova, V., Hesova, R., Tichy, F., Faldyna, M., Taştan, Y., Kotoucek, J., Svobodova, Z., Lakdawala, P. (2023) Medicine designed to combat diseases of affluence affects the early development of fish. How do plastic microparticles contribute?. The Science of the total environment. 904:166378
- Yehuda, H., Madrer, N., Goldberg, D., Soreq, H., Meerson, A. (2023) Inversely Regulated Inflammation-Related Processes Mediate Anxiety-Obesity Links in Zebrafish Larvae and Adults. Cells. 12(13):
- Zasu, A., Hishima, F., Thauvin, M., Yoneyama, Y., Kitani, Y., Hakuno, F., Volovitch, M., Takahashi, S.I., Vriz, S., Rampon, C., Kamei, H. (2022) NADPH-Oxidase Derived Hydrogen Peroxide and Irs2b Facilitate Re-oxygenation-Induced Catch-Up Growth in Zebrafish Embryo. Frontiers in endocrinology. 13:929668
- Fei, F., Sun, S., Li, Q., Pei, Z., Wang, L., Zhang, R., Luo, F., Yu, M., Wang, X. (2020) Combinatorial normalization of liver-derived cytokine pathways alleviates hepatic tumor-associated cachexia in zebrafish. Cancer research. 81(4):873-884
- Knuth, M.M., Mahapatra, D., Jima, D., Wan, D., Hammock, B.D., Law, M., Kullman, S.W. (2020) Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Scientific Reports. 10:16032
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
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