Gene

unga

ID

ZDB-GENE-040426-900

Name

uracil DNA glycosylase a

Symbol

unga Nomenclature History

Previous Names

ung
zgc:56102 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Exhibits G/U mismatch-specific uracil-DNA glycosylase activity. Involved in histone lysine methylation and regulation of nucleobase-containing compound metabolic process. Predicted to localize to mitochondrion and nucleus. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Is expressed in blastomere; oocyte stage I; and oocyte stage II. Orthologous to human UNG (uracil DNA glycosylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56102 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Wu et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With unga Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency with hyper IgM type 5	Alliance	Immunodeficiency with hyper IgM, type 5	608106

Associated With unga Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018085	Uracil-DNA glycosylase, active site
Domain	IPR005122	Uracil-DNA glycosylase-like
Family	IPR002043	Uracil-DNA glycosylase family 1
Homologous_superfamily	IPR036895	Uracil-DNA glycosylase-like domain superfamily