Gene
eps8a
- ID
- ZDB-GENE-040426-871
- Name
- EGFR pathway substrate 8a, signaling adaptor
- Symbol
- eps8a Nomenclature History
- Previous Names
-
- eps8
- zgc:56041 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm. Predicted to be active in ruffle membrane. Is expressed in nervous system; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (EGFR pathway substrate 8, signaling adaptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56041 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 102 | Alliance | ?Deafness, autosomal recessive 102 | 615974 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001452 | SH3 domain |
| Domain | IPR006020 | PTB/PI domain |
| Domain | IPR013625 | Tensin/EPS8 phosphotyrosine-binding domain |
| Domain | IPR033928 | Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain |
| Domain | IPR035462 | Eps8, SH3 domain |
| Domain | IPR041418 | SAM domain |
| Domain | IPR055093 | EPS8, spectrin-like domain |
| Family | IPR039801 | Epidermal growth factor receptor kinase substrate 8-like |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Epidermal growth factor receptor kinase substrate 8-like | Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain | Eps8, SH3 domain | EPS8, spectrin-like domain | PH-like domain superfamily | PTB/PI domain | SAM domain | SH3 domain | SH3-like domain superfamily | Sterile alpha motif/pointed domain superfamily | Tensin/EPS8 phosphotyrosine-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IIJ9 | InterPro | ||||||||||||
| UniProtKB:A0A8M3B1E2 | InterPro | 852 | |||||||||||
| UniProtKB:Q7ZUV6 | InterPro | 804 | |||||||||||
| UniProtKB:A0A8M3ARA8 | InterPro | 819 | |||||||||||
| UniProtKB:A0A8M3AYF2 | InterPro | 872 | |||||||||||
| UniProtKB:A0A8M3B8N1 | InterPro | 869 | |||||||||||
| UniProtKB:A0A8M3AYF5 | InterPro | 851 | |||||||||||
| UniProtKB:A0A8M3B1E6 | InterPro | 857 | |||||||||||
| UniProtKB:A0A8M3ARA4 | InterPro | 864 | |||||||||||
| UniProtKB:A0A8M6Z5A1 | InterPro | 871 | |||||||||||
| UniProtKB:A0A8M3B8N5 | InterPro | 838 | |||||||||||
| UniProtKB:A0A8M3AR15 | InterPro | 871 | |||||||||||
| UniProtKB:A0A0R4IID9 | InterPro | 804 | |||||||||||
| UniProtKB:A0A8M6YXX0 | InterPro | 838 | |||||||||||
| UniProtKB:A0A8M3AR20 | InterPro | 839 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available