Gene
umps
- ID
- ZDB-GENE-040426-785
- Name
- uridine monophosphate synthetase
- Symbol
- umps Nomenclature History
- Previous Names
-
- zgc:55702 (1)
- zgc:55723
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have orotate phosphoribosyltransferase activity and orotidine-5'-phosphate decarboxylase activity. Predicted to be involved in UMP biosynthetic process and pyrimidine nucleobase biosynthetic process. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Is expressed in several structures, including alar plate midbrain region; central nervous system; immature eye; mesoderm; and yolk syncytial layer. Orthologous to human UMPS (uridine monophosphate synthetase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55723 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| orotic aciduria | Alliance | Orotic aciduria | 258900 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018089 | Orotidine 5'-phosphate decarboxylase, active site |
| Domain | IPR000836 | Phosphoribosyltransferase domain |
| Domain | IPR001754 | Orotidine 5'-phosphate decarboxylase domain |
| Domain | IPR004467 | Orotate phosphoribosyl transferase domain |
| Family | IPR014732 | Orotidine 5'-phosphate decarboxylase |
| Family | IPR023031 | Orotate phosphoribosyltransferase |
| Homologous_superfamily | IPR011060 | Ribulose-phosphate binding barrel |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR029057 | Phosphoribosyltransferase-like |
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | Orotate phosphoribosyltransferase | Orotate phosphoribosyl transferase domain | Orotidine 5'-phosphate decarboxylase | Orotidine 5'-phosphate decarboxylase, active site | Orotidine 5'-phosphate decarboxylase domain | Phosphoribosyltransferase domain | Phosphoribosyltransferase-like | Ribulose-phosphate binding barrel |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B8JLL1
|
479 |
Interactions and Pathways
No data available
Plasmids
No data available