Gene
tax1bp3
- ID
- ZDB-GENE-040426-2830
- Name
- Tax1 (human T-cell leukemia virus type I) binding protein 3
- Symbol
- tax1bp3 Nomenclature History
- Previous Names
-
- wu:fb37e03
- wu:fc23g08
- zgc:55513
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Acts upstream of or within convergent extension involved in axis elongation. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Is expressed in brain; eye; heart; and immature eye. Orthologous to human TAX1BP3 (Tax1 binding protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909466 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Besser et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010917Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tax1bp3 | N/A | Besser et al., 2007 |
| MO2-tax1bp3 | N/A | Besser et al., 2007 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | PDZ domain | PDZ superfamily | Synaptic Scaffolding LAP/MAGUK Families | Tax1-binding protein 3 |
|---|---|---|---|---|---|
|
UniProtKB:Q8AWD4
|
125 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tax1bp3-201
(1)
|
Ensembl | 1,273 nt | ||
| ncRNA |
tax1bp3-002
(1)
|
Ensembl | 715 nt | ||
| ncRNA |
tax1bp3-003
(1)
|
Ensembl | 950 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-236O17 | ZFIN Curated Data | |
| Encodes | EST | fb37e03 | ZFIN Curated Data | |
| Encodes | EST | fc23g08 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6909466 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55513 | ZFIN Curated Data | |
| Has Artifact | EST | fa10d03 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213470 (1) | 1248 nt | ||
| Genomic | GenBank:BX248501 (2) | 93385 nt | ||
| Polypeptide | UniProtKB:Q8AWD4 (1) | 125 aa |
- Matsukawa, T., Morita, K., Omizu, S., Kato, S., Koriyama, Y. (2017) Mechanisms of RhoA inactivation and CDC42 and Rac1 activation during zebrafish optic nerve regeneration. Neurochemistry international. 112:71-80
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nolte, H., Hölper, S., Housley, M.P., Islam, S., Piller, T., Konzer, A., Stainier, D.Y., Braun, T., Krüger, M. (2015) Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Proteomics. 15(4):739-51
- Reinstein, E., Orvin, K., Tayeb-Fligelman, E., Stiebel-Kalish, H., Tzur, S., Pimienta, A.L., Bazak, L., Bengal, T., Cohen, L., Gaton, D.D., Bormans, C., Landau, M., Kornowski, R., Shohat, M., Behar, D.M. (2015) Mutations in TAX1BP3 cause Dilated Cardiomyopathy with Septo-Optic Dysplasia. Human Mutation. 36(4):439-42
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, L., Fu, C., Fan, H., Du, T., Dong, M., Chen, Y., Jin, Y., Zhou, Y., Deng, M., Gu, A., Jing, Q., Liu, T., and Zhou, Y. (2013) miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development (Cambridge, England). 140(13):2755-2764
- Besser, J., Leito, J.T., van der Meer, D.L., and Bagowski, C.P. (2007) Tip-1 induces filopodia growth and is important for gastrulation movements during zebrafish development. Development, growth & differentiation. 49(3):205-214
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Harden, M.V., Newton, L.A., Lloyd, R.C., Whitlock, K.E. (2006) Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Journal of neurobiology. 66(13):1452-1466
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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