Gene

eif4a2

ID

ZDB-GENE-040426-2802

Name

eukaryotic translation initiation factor 4A2

Symbol

eif4a2 Nomenclature History

Previous Names

wu:fd50g11
zgc:63783 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have RNA helicase activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Is expressed in several structures, including alar plate midbrain region; head; immature eye; midbrain; and segmental plate. Orthologous to human EIF4A2 (eukaryotic translation initiation factor 4A2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

20 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6906198 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eif4a2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neurodevelopmental disorder with hypotonia and speech delay	Alliance	Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures	620455

Associated With eif4a2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR011545	DEAD/DEAH box helicase domain
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR014014	RNA helicase, DEAD-box type, Q motif
Domain	IPR044728	ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase