Gene

fpgs

ID

ZDB-GENE-040426-2781

Name

folylpolyglutamate synthase

Symbol

fpgs Nomenclature History

Previous Names

fk51d09
wu:fk49h03
wu:fk51d09
zgc:63807

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable tetrahydrofolylpolyglutamate synthase activity. Predicted to be involved in tetrahydrofolylpolyglutamate biosynthetic process. Predicted to act upstream of or within folic acid-containing compound biosynthetic process and one-carbon metabolic process. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alar plate midbrain region; liver; nervous system; optic vesicle; and yolk syncytial layer. Orthologous to human FPGS (folylpolyglutamate synthase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63807 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fpgs Human Ortholog

No data available

Associated With fpgs Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018109	Folylpolyglutamate synthetase, conserved site
Family	IPR001645	Folylpolyglutamate synthetase
Family	IPR023600	Folylpolyglutamate synthase, eukaryota
Homologous_superfamily	IPR036565	Mur-like, catalytic domain superfamily
Homologous_superfamily	IPR036615	Mur ligase, C-terminal domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Folylpolyglutamate synthase, eukaryota	Folylpolyglutamate synthetase	Folylpolyglutamate synthetase, conserved site	Mur ligase, C-terminal domain superfamily	Mur-like, catalytic domain superfamily
UniProtKB:F1Q7N0	InterPro	572

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fpgs-201 (1) Ensembl	Ensembl	2,553 nt	Select Tool ZFIN BLAST
mRNA	fpgs-203 (1) Ensembl	Ensembl	3,192 nt	Select Tool ZFIN BLAST
ncRNA	fpgs-002 (1) Ensembl	Ensembl	659 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations