Gene
uba2
- ID
- ZDB-GENE-040426-2681
- Name
- ubiquitin-like modifier activating enzyme 2
- Symbol
- uba2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable SUMO activating enzyme activity. Acts upstream of or within several processes, including fin morphogenesis; regulation of cartilage development; and regulation of neural retina development. Predicted to be located in nucleus. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Is expressed in forebrain neural rod; head; nervous system; pectoral fin bud; and somite. Orthologous to human UBA2 (ubiquitin like modifier activating enzyme 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66354 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Schnur et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ACCES syndrome | 619959 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR033127 | Ubiquitin-activating enzyme E1, Cys active site |
| Domain | IPR000594 | THIF-type NAD/FAD binding fold |
| Domain | IPR028077 | Ubiquitin/SUMO-activating enzyme ubiquitin-like domain |
| Domain | IPR032426 | SUMO-activating enzyme subunit 2, C-terminal domain |
| Family | IPR030661 | SUMO-activating enzyme subunit Uba2 |
| Family | IPR045886 | ThiF/MoeB/HesA family |
| Homologous_superfamily | IPR023318 | Ubiquitin activating enzyme, alpha domain superfamily |
| Homologous_superfamily | IPR035985 | Ubiquitin-activating enzyme |
| Homologous_superfamily | IPR042449 | Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 |
Domain Details Per Protein
| Protein | Additional Resources | Length | SUMO-activating enzyme subunit 2, C-terminal domain | SUMO-activating enzyme subunit Uba2 | ThiF/MoeB/HesA family | THIF-type NAD/FAD binding fold | Ubiquitin-activating enzyme | Ubiquitin activating enzyme, alpha domain superfamily | Ubiquitin-activating enzyme E1, Cys active site | Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 | Ubiquitin/SUMO-activating enzyme ubiquitin-like domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ANZ0 | InterPro | 640 | |||||||||
| UniProtKB:Q7SXG4 | InterPro | 650 | |||||||||
| UniProtKB:B2GQ09 | InterPro | 640 | |||||||||
| UniProtKB:A0A8M3AWE5 | InterPro | 641 |
Interactions and Pathways
No data available
Plasmids
No data available