Gene
ercc1
- ID
- ZDB-GENE-040426-2606
- Name
- excision repair cross-complementation group 1
- Symbol
- ercc1 Nomenclature History
- Previous Names
-
- zgc:77511
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process. Predicted to localize to ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Human ortholog(s) of this gene implicated in several diseases, including bone cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); kidney failure; and transient cerebral ischemia. Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zaksauskaite et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebrooculofacioskeletal syndrome 4 | Alliance | Cerebrooculofacioskeletal syndrome 4 | 610758 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ERCC1-like, central domain | ERCC1/RAD10/SWI10 family | Restriction endonuclease type II-like | RuvA domain 2-like |
|---|---|---|---|---|---|
|
UniProtKB:Q6NY87
|
342 |
Interactions and Pathways
No data available
Plasmids
No data available