Gene
rnf170
- ID
- ZDB-GENE-040426-2572
- Name
- ring finger protein 170
- Symbol
- rnf170 Nomenclature History
- Previous Names
-
- zgc:65779
- zgc:76995 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Acts upstream of or within chordate embryonic development. Predicted to be located in endoplasmic reticulum membrane. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in autosomal dominant sensory ataxia 1 and hereditary spastic paraplegia 85. Orthologous to human RNF170 (ring finger protein 170).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76995 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant sensory ataxia 1 | Alliance | Ataxia, sensory, 1, autosomal dominant | 608984 |
| hereditary spastic paraplegia 85 | Alliance | Spastic paraplegia 85, autosomal recessive | 619686 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hereditary spastic paraplegia | WT + MO3-rnf170 | standard conditions | Wagner et al., 2019 |
| hereditary spastic paraplegia | WT + MO4-rnf170 | standard conditions | Wagner et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR010652 | Domain of unknown function DUF1232 |
| Domain | IPR027370 | Zinc finger, RING-type, eukaryotic |
| Family | IPR038896 | E3 ubiquitin-protein ligase RNF170 |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Additional Resources | Length | Domain of unknown function DUF1232 | E3 ubiquitin-protein ligase RNF170 | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, RING-type, eukaryotic |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SZN2 | InterPro | 266 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rnf170-201
(1)
|
Ensembl | 1,862 nt | ||
| mRNA |
rnf170-202
(1)
|
Ensembl | 2,898 nt |
Interactions and Pathways
No data available
Plasmids
No data available