Gene

pnp5a

ID

ZDB-GENE-040426-2553

Name

purine nucleoside phosphorylase 5a

Symbol

pnp5a Nomenclature History

Previous Names

np
wu:fd51h11
zgc:77008 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable purine-nucleoside phosphorylase activity. Predicted to act upstream of or within nucleoside metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pnp5a Human Ortholog

No data available

Associated With pnp5a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000845	Nucleoside phosphorylase domain
Family	IPR011268	Purine nucleoside phosphorylase
Family	IPR011270	Purine nucleoside phosphorylase I, inosine/guanosine-specific
Homologous_superfamily	IPR035994	Nucleoside phosphorylase superfamily

Domain Details Per Protein

Protein	Length	Nucleoside phosphorylase domain	Nucleoside phosphorylase superfamily	Purine nucleoside phosphorylase	Purine nucleoside phosphorylase I, inosine/guanosine-specific
UniProtKB:Q6NYG0 InterPro	293

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pnp5a-201 (1) Ensembl	Ensembl		3,076 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: Woods et al. (ZDB-PUB-050823-6) reported orthology to human PNP based on AA. Based on a personal communication from D. Raible, the orthology reported by Woods, et al. has been removed.

Citations