Gene
loxa
- ID
- ZDB-GENE-040426-2398
- Name
- lysyl oxidase a
- Symbol
- loxa Nomenclature History
- Previous Names
-
- lox
- zgc:77447 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have protein-lysine 6-oxidase activity. Involved in cartilage development; muscle organ development; and neurogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; hypertension; and thoracic aortic aneurysm. Is expressed in brain; head; muscle; notochord; and pectoral fin. Orthologous to human LOX (lysyl oxidase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Reynaud et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Aortic aneurysm, familial thoracic 10 | 617168 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Immunoglobulin-like fold | Lysyl oxidase | Lysyl oxidase, conserved site |
|---|---|---|---|---|
|
UniProtKB:Q6NYT8
|
408 |
Interactions and Pathways
No data available
Plasmids
No data available