Gene

dusp16

ID

ZDB-GENE-040426-2360

Name

dual specificity phosphatase 16

Symbol

dusp16 Nomenclature History

Previous Names

wu:fi04g09
zgc:77247 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade and signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human DUSP16 (dual specificity phosphatase 16).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

No data available

Sequence Targeting Reagents

No data available

Human Disease

Associated With dusp16 Human Ortholog

No data available

Associated With dusp16 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016130	Protein-tyrosine phosphatase, active site
Domain	IPR000340	Dual specificity phosphatase, catalytic domain
Domain	IPR000387	Tyrosine-specific protein phosphatases domain
Domain	IPR001763	Rhodanese-like domain
Domain	IPR020422	Dual specificity protein phosphatase domain

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Domain Details Per Protein

Protein	Length	Dual specificity phosphatase, catalytic domain	Dual specificity protein phosphatase domain	Mitogen-activated protein (MAP) kinase phosphatase	Protein-tyrosine phosphatase, active site	Protein-tyrosine phosphatase-like	Rhodanese-like domain	Rhodanese-like domain superfamily	Tyrosine-specific protein phosphatases domain
UniProtKB:F1RDV6 InterPro	539

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 4

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	dusp16-201 (1) Ensembl	Ensembl		4,959 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	Fosmid	CH1073-159I21	FP085386	ZFIN Curated Data
Encodes	EST	fi04g09	AW115897 AW127923	ZFIN Curated Data
Encodes	cDNA	MGC:77247	BC067137	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_213240 (1)	4927 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:FP085386 (2)	31607 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1RDV6 (1)	539 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	DUSP16	12	Ensembl:ENSG00000111266 Ensembl:ENSG00000280962 Gene:80824 OMIM:607175 HGNC:17909	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Dusp16	6	Ensembl:ENSMUSG00000030203 MGI:1917936 Gene:70686	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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